n millions of people worldwide, the pancreas is under attack! Damage to cells in the pancreas leads to type 1 diabetes, this destruction has largely been hidden from view - until now. Investigators at the La Jolla Institute for Allergy & Immunology have produced the first cellular movies demonstrating the destruction underlying type 1 diabetes in real-time mouse models, providing the worldwide scientific community with insights into this disease process as never before possible. This detailed, dynamic view might greatly affect the directions in diabetes type 1 R&D.
Matthias von Herrath, M.D. one of the world's leading type 1 diabetes experts, and director of the Diabetes Research Center at the La Jolla Institute for Allergy & Immunology, explained:
"We are presenting the first images at cellular resolution of type 1 diabetes as-it-unfolds. Being able to view these insulin-producing cells while they interact in the pancreas, rather than in a static state under the microscope, will greatly enhance our ability - and that of the broader scientific community - to find interventions for type 1 diabetes."
A report on the scientific findings of the study, in conjunction with the cellular movies taken by the scientists, are published online in the Journal of Clinical Investigation. The movies are freely available and can be viewed at the end of the article. Ken Coppieters, Ph.D., formerly of the La Jolla Institute and now at Ghent University, Belgium, is first author on the investigation. Dr. von Herrath is senior author
No comments:
Post a Comment